Stem cells from adipose tissue improve the time of wound healing in rats
Acta cir. bras
; 31(12): 821-825, Dec. 2016. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-837663
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats.METHODS:
Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.RESULTS:
All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.CONCLUSION:
Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Células-Tronco
/
Cicatrização
/
Ferimentos e Lesões
/
Tecido Adiposo
/
Transplante de Células-Tronco
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Pará/BR