The effects of cerebral hemidecortication on the eruption rate and uptake of [3H]-glycine by the periodontal ligament of the rat incisor / Efeito do hemidecorticação cerebral em relação a erupção e incorporação (3h) glicine no ligamento periodontal do incisivo de rato

ABSTRACT

Hemidecortication, which consists of removing one cerebral hemisphere, leaving intact the thalamus and hypothalamus, affects the hypothalamus-hypophyseal axis producing hypothyroidism. Hemidecorticate rats showed a significant decrease in the weekly eruption rate of the upper incisors and partial recovery after administration of thyrotrophin-releasing hormone (TRH). The uptake of [3H]-glycine, 1 and 4 h after a single injection, shown by radioautography, was 25 to 50 per cent higher in the periodontal ligament of the experimental animals. Most of the labelled material was noncollagenous proteins because only 20 to 30 per cent was removed by collagenase