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Hypodontia: genetics and future perspectives% Hipodontia: genética e perspectivas futuras
Braz. j. oral sci ; 4(13): 695-706, Apr.-June 2005. ilus, tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-872649
Biblioteca responsável: BR218.1
Localização: BR28.1; BR97.1
ABSTRACT
Tooth development is a complex process of reciprocal interactions that we have only recently begun to understand. With the large number of genes involved in the odontogenic process, the opportunity for mutations to disrupt this process is high. Tooth agenesis (hypodontia)is the most common craniofacial malformation with patients missing anywhere from one tooth to their entire dentition. Hypodontia can occur in association with other developmental anomalies (syndromic) or as an isolated condition (non-syndromic). Recent advances in genetictechniques have allowed us to begin understanding the genetic processes that underlie the odontogenic process and to identify the mechanisms responsible for tooth agenesis. Thus far two genes have been identifiedby mutational analysis as the major causes of non-syndromic hypodontia; PAX9 and MSX1. Haploinsufficiency of either has been observed to cause the more severe forms of hypodontia whilst point mutations cause hypodontia to varying degrees of severity. With theprevalence of hypodontia having been observed to have increased during the 20th century, the future identification and analysis of its geneticbasis is essential to allow us to better treat the condition. The clinician can facilitate this process by collaborating with the human geneticist and referring patients/families with familial hypodontia for investigative research
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Coleções: Bases de dados internacionais Base de dados: BBO - Odontologia / LILACS Assunto principal: Anodontia Tipo de estudo: Prevalence_studies Idioma: Inglês Revista: Braz. j. oral sci Assunto da revista: Odontologia Ano de publicação: 2005 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: Anderson cancer Center/US / Institute of Genetic Medicine/US / University of Southern California/US