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The effects of subcutaneous injection of nicotine on osseointegration of machined and anodized implants in rabbits
Linden, Maria Salete Sandini; Bittencourt, Marcos Eugênio de; Carli, João Paulo De; Miyagaki, Daniela Cristina; Santos, Pâmela Letícia dos; Paranhos, Luiz Renato; Groppo, Francisco Carlos; Ramacciato, Juliana Cama.
Afiliação
  • Linden, Maria Salete Sandini; Universidade de Passo Fundo. Department of Dentistry. BR
  • Bittencourt, Marcos Eugênio de; Universidade de Passo Fundo. Department of Dentistry. BR
  • Carli, João Paulo De; Universidade de Passo Fundo. Department of Dentistry. BR
  • Miyagaki, Daniela Cristina; Universidade de Passo Fundo. Department of Dentistry. BR
  • Santos, Pâmela Letícia dos; Universidade de Passo Fundo. Department of Dentistry. BR
  • Paranhos, Luiz Renato; Universidade de Passo Fundo. Department of Dentistry. BR
  • Groppo, Francisco Carlos; Universidade de Passo Fundo. Department of Dentistry. BR
  • Ramacciato, Juliana Cama; Universidade de Passo Fundo. Department of Dentistry. BR
Acta cir. bras ; 33(1): 31-39, Jan. 2018. graf
Artigo em Inglês | LILACS | ID: biblio-886250
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To evaluate the influence of subcutaneous injection nicotine in osseointegration process on different implant surfaces.

Methods:

Twenty-two male rabbits were distributed into two groups according to the subcutaneous injections (1) nicotine 3 mg/day/kg and (2) 0.9 % NaCI 3 mL/day/kg, three times a day; subgroups were then designated-machined and anodized implants were placed in the right and left tibia bones, respectively. The animals were submitted euthanasia after periods of eight weeks to determine nicotine and cotinine levels, alkaline phosphatase and biomechanical analysis.

Results:

The plasmatic levels of nicotine and cotinine were 0.5 ± 0.28 ng/mL and 9.5 ± 6.51 ng/mL, respectively. The alkaline phosphatase analyses in blood levels in control group were observed 40.8 ± 11.88 UI/L and 40.75 ± 12.46 UI/L, for the surfaces machined and anodized, respectively. In the test group was observed levels 37.9 ± 4.84 UI/L, for both implant surfaces. No significant differences were observed between control and test groups and between the implant surfaces regarding alkaline phosphatase blood levels. For biomechanics, no significant differences were observed in control group between the machined (25±8.46 Ncm) or anodized (31.2 ± 6.76 Ncm) implants. However, the treatment with nicotine induced higher torque than control in both machined (38.3 ± 13.52 Ncm) and anodized (35.5 ± 14.17 Ncm) implants, with p = 0.0024 and p = 0.0121, respectively.

Conclusion:

Subcutaneous injection of nicotine following implant insertion didn't have effect on osseointegration, independently from the implant surface.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Implantes Dentários / Osseointegração / Interface Osso-Implante / Nicotina Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade de Passo Fundo/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Implantes Dentários / Osseointegração / Interface Osso-Implante / Nicotina Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade de Passo Fundo/BR
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