Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion
Acta cir. bras
; 33(2): 125-133, Feb. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-886259
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To investigate the biochemical, histopathologic, and spermatogenetic changes in the detorsionated testicle after experimental torsion and to study the antioxidant effects of pheniramine maleate and nebivolol.Methods:
Twenty-four Sprague-Dawley male rats were divided into 4 groups Group 1 Sham; Group 2 Torsion/Detorsion (T/D); Group 3 T/D + Pheniramine maleate (PM); Group 4 T/D + Nebivolol (NB) group. Paroxanase (PON), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stres index (OSI) were measured, and spermatogenetic and histopathologic evaluation was performed in tissue and blood samples.Results:
The evaluation of tissue TAS indicated no statistically significant difference in Group 3 compared to Group 2. A statistically significant increase was detected in Group 4 compared to Group 2. Serum PON levels revealed a statistically significant increase in Groups 3 and 4 compared to Groups 1 and 2. The Johnsen testicular biopsy score decreased in Groups 3 and 4, but the decrease was not statistically significant.Conclusions:
Pheniramine maleate and nebivolol have antioxidant effects against ischemia-reperfusion damage. They also support tissue recovery, which is more significantly observed by nebivolol.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Feniramina
/
Torção do Cordão Espermático
/
Testículo
/
Estresse Oxidativo
/
Nebivolol
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
University of Kirikkale/TR