Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
An. acad. bras. ciênc
; 89(1,supl): 635-647, May. 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-886672
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI GD 9, 91/2 or 10; DBA/2J GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Esqueleto
/
Teratógenos
/
Somitos
/
Desenvolvimento Embrionário
/
Embrião de Mamíferos
/
Metilnitrosoureia
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
An. acad. bras. ciênc
Assunto da revista:
Ciência
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Alemanha
Instituição/País de afiliação:
Charité - Universitätsmedizin Berlin/DE