Study of serum levels and skin expression of S100B protein in psoriasis
An. bras. dermatol
; 92(3): 323-328, May-June 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-886968
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
S100B protein was reported to be elevated in psoriatic patients' serum, with no previous evaluation of its skin expression, in contrast to the extensively studied S100 protein.Objective:
To evaluate the serum level and skin expression of S100B in psoriasis to assess its possible involvement in its pathogenesis.Methods:
Serum level of S100B protein was estimated in 40 psoriatic patients of different clinical varieties and 10 healthy controls. S100B protein expression was assessed immunohistochemically in lesional and non-lesional skin of patients and in normal skin of controls. Relation to disease severity was also evaluated.Results:
Serum level of S100B protein was significantly higher in psoriatic patients (0.15±0.03 µg/l) than in controls (0.03±0.007 µg/l) (P-value <0.001) with no significant correlation with PASI score. On comparing grades of S100B protein skin expression in lesional and non-lesional skin biopsies, a statistically significant difference was found (P=0.046) with higher percentage of strong S100B skin expression (60%) in non-lesional than in lesional (42%) skin. All the control biopsies showed negative expression. Studylimitations:
Relatively small sample size with a limited range of low PASI scores.Conclusion:
This study points to a potential link between psoriasis and S100B protein with higher serum and skin expression in patients than in controls.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Psoríase
/
Subunidade beta da Proteína Ligante de Cálcio S100
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Egito
Instituição/País de afiliação:
Ain Shams University/EG