Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma
J. oral res. (Impresa)
; 6(2): 39-45, Feb. 2017. tab, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-907706
Biblioteca responsável:
CL30.1
ABSTRACT
To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods:
Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31.Results:
Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17 +/- 4.98 in NOM, 23.40 +/- 5.77 in OED and 33.92 +/- 8.39 in OSCC.Conclusion:
EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Fator de Crescimento Epidérmico
/
Mucosa Bucal
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. oral res. (Impresa)
Assunto da revista:
Odontologia
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Chile
/
México
Instituição/País de afiliação:
Universidad Andrés Bello/CL
/
Universidad de Chile/CL
/
Universidad de Los Andes/CL