SIVA, a target of p53, is downregulated in myelodysplastic syndromes
Appl. cancer res
; 37: 1-7, 2017. tab, ilus
Artigo
em Inglês
| LILACS, Inca
| ID: biblio-915402
Biblioteca responsável:
BR30.1
ABSTRACT
Background:
SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its association with clinical features and TP53 and MDM2 expression in bone marrow cells from healthy donors and myelodysplastic syndrome (MDS) patients.Methods:
Fifty-five untreated patients with MDS and 22 healthy donors were included. Gene expression was evaluated by quantitative PCR. For statistical analysis, MannWhitney test, Spearman correlation analysis and Log-rank (Mantel-Cox) were used, as appropriate. A p value <0.05 was considered statistically significant.Results:
SIVA1 and SIVA2 transcripts were significantly decreased in bone marrow samples from MDS patients compared to healthy donors, and positively correlated with MDM2 and TP53 expression in MDS patients (all p < 0.05). MDM2 expression was also downregulated in bone marrow samples from MDS patients compared to healthy donors (p < 0.05). However, SIVA1, SIVA2, MDM2 and TP53 expressions did not impact on MDS outcomes.Conclusions:
SIVA1 and SIVA2 transcripts are downregulated in bone marrow samples from MDS patients (AU)
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
/
Inca
Assunto principal:
Síndromes Mielodisplásicas
/
Genes p53
/
Fator de Indução de Apoptose
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
University of Campinas, Hemocentro-Unicamp/BR