Use of Amifostine in the Therapy of Osteosarcomain Children and Adolescents
J. pediatr. hematol. oncol
; 24(3): 188-191, 2002.
Article
em En
| ColecionaSUS
| ID: biblio-945230
Biblioteca responsável:
BR440.1
Localização: BR440.1
ABSTRACT
Amifostine protects normal tissue from the cytotoxic damage induced by radiation and chemotherapy. In this study, 39 consecutive newly diagnosed children with osteosarcoma were assessed; 20 received amifostine and 19 did not. The chemotherapy regimen included an induction phase of three cycles of cisplatin (100 mg/m2), carboplatin (500 mg/m2), and doxorubicin (60 mg/m2), followed by surgery. Alternating cycles of cisplatin/ifosfamide (9 mg/m2), ifosfamide/doxorubicin, carboplatin/doxorubicin, and ifosfamide/carboplatin were administered every 3 weeks to complete 26 weeks of treatment. Amifostine was administered 15 minutes before the infusions of cisplatin and carboplatin in a total of 193 infusions. Side effects during infusions and renal, hearing, and bone marrow toxicities were evaluated and compared between the two groups. Hypotension was observed in 28 (14.5%) infusions. No patient required discontinuation of therapy. Fewer than two episodes of vomiting occurred in 130 (71%) infusions and two to five episodes occurred in 51 (28%) infusions, and no patient had grade 4 toxicity. There was no difference between the two groups regarding renal toxicity (creatinine clearance). Neutropenia and leukopenia were significantly less frequent in the amifostine group. No difference was observed in platelet and hearing toxicities. Amifostine was well tolerated in doses of 740 mg/m2 in children and adolescents, and myelotoxicity was less severe in the amifostine group. This was a pilot study for further evaluation in a larger randomized trial.
Buscar no Google
Coleções:
06-national
/
BR
Base de dados:
ColecionaSUS
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Doxorrubicina
/
Osteossarcoma
/
Carboplatina
/
Cisplatino
/
Amifostina
/
Ifosfamida
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J. pediatr. hematol. oncol
Ano de publicação:
2002
Tipo de documento:
Article