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Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity
Brihoum, Hadjer; Maiza, Mhamed; Sahali, Hafida; Boulmeltout, Malika; Barratt, Gillian; Benguedouar, Lamia; Lahouel, Mesbah.
Afiliação
  • Brihoum, Hadjer; University of Jijel. Faculty of Science. Department of Natural and Life Science. DZ
  • Maiza, Mhamed; Jijel Hospital. Biochemestry Service. Jijel. DZ
  • Sahali, Hafida; Jijel Hospital. Oncology Service. Jijel. DZ
  • Boulmeltout, Malika; University of Jijel. Faculty of Science. Department of Natural and Life Science. DZ
  • Barratt, Gillian; University of Paris-Sud XI. Faculty of Pharmacy. FR
  • Benguedouar, Lamia; University of Jijel. Faculty of Science. Department of Natural and Life Science. DZ
  • Lahouel, Mesbah; University of Jijel. Faculty of Science. Department of Natural and Life Science. DZ
Braz. J. Pharm. Sci. (Online) ; 54(1): e17396, 2018. tab, graf
Article em En | LILACS | ID: biblio-951903
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Abstract The purpose of our study was to divulge the antiproliferative effect of an ethanolic extract of Algerian propolis (EEP) in the human lung adenocarcinoma cell line (A549) and reveal the chemopreventive role against benzo(a)pyrene-induced lung carcinogenesis in albino Wistar rats. Cytotoxicity of EEP was evaluated using the MTT assay and cell adhesion in A549 cells. Moreover, rats were given 25 mg/kg of propolis for 5 days before induction of experimental lung cancer by a single intraperitoneal dose of 200 mg/kg benzo(a)pyrene. Body weight, lung weight, lipid peroxidation, marker enzymes, and enzymatic and non-enzymatic antioxidants were estimated. The EEP demonstrated an inhibitory effect on proliferation of A549 at 24 and 72 hours in a dose-dependent manner and blocked adhesion of the cells by fibrinogen. Moreover, EEP reduced the oxidative stress generated by benzo(a)pyrene. The pre-treatment showed that enzymatic and non-enzymatic antioxidants increased and lipid peroxidation decreased. A histological analysis further supported these findings and showed a decrease in the number of side effects. These results are particularly important for both clinical applications of propolis and the possibility for its use as a potential chemotherapeutic agent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Própole / Quimioprevenção / Neoplasias Pulmonares / Antioxidantes Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argélia / França País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Própole / Quimioprevenção / Neoplasias Pulmonares / Antioxidantes Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argélia / França País de publicação: Brasil