Marine drugs for cancer: surfacing biotechnological innovations from the oceans
Clinics
; 73(supl.1): e482s, 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-952842
Biblioteca responsável:
BR1.1
ABSTRACT
This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this endeavor, such as toxicity and supply. In this context, the development of these compounds will be discussed herein to illustrate, with successful examples provided by cytarabine, trabectedin, eribulin and brentuximab vedotin, the steps involved in this process as well as the scientific advances and technological innovation potential associated with developing a new drug from marine resources.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Biotecnologia
/
Organismos Aquáticos
/
Desenvolvimento de Medicamentos
/
Neoplasias
/
Antineoplásicos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Sao Paulo/BR
/
Universidade Federal do Ceara/BR
/
Universidade de Sao Paulo/BR