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Multiple uses of fibrin sealant for nervous system treatment following injury and disease
Biscola, Natalia Perussi; Cartarozzi, Luciana Politti; Ulian-Benitez, Suzana; Barbizan, Roberta; Castro, Mateus Vidigal; Spejo, Aline Barroso; Ferreira Junior, Rui Seabra; Barraviera, Benedito; Oliveira, Alexandre Leite Rodrigues.
Afiliação
  • Biscola, Natalia Perussi; Universidade Estadual Paulista. Botucatu Medical School. Botucatu. BR
  • Cartarozzi, Luciana Politti; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
  • Ulian-Benitez, Suzana; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
  • Barbizan, Roberta; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
  • Castro, Mateus Vidigal; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
  • Spejo, Aline Barroso; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
  • Ferreira Junior, Rui Seabra; Universidade Estadual Paulista. Botucatu Medical School. Botucatu. BR
  • Barraviera, Benedito; Universidade Estadual Paulista. Botucatu Medical School. Botucatu. BR
  • Oliveira, Alexandre Leite Rodrigues; University of Campinas. Institute of Biology. Department of Structural and Functional Biology. Campinas. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;23: 13, 2017. graf, ilus
Article em En | LILACS, VETINDEX | ID: biblio-954819
Biblioteca responsável: BR68.1
ABSTRACT
Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery. To date, several studies have demonstrated that human blood derived fibrin sealant produces positive effects in different interventions, becoming an efficient alternative to suturing. To provide an alternative to homologous fibrin sealants, the Center for the Study of Venoms and Venomous Animals (CEVAP, Brazil) has proposed a new bioproduct composed of certified animal components, including a thrombin-like enzyme obtained from snake venom and bubaline fibrinogen. Thus, the present review brings up to date literature assessment on the use of fibrin sealant for nervous system repair and positions the new heterologous bioproduct from CEVAP as an alternative to the commercial counterparts. In this way, clinical and pre-clinical data are discussed in different topics, ranging from central nervous system to peripheral nervous system applications, specifying positive results as well as future enhancements that are necessary for improving the use of fibrin sealant therapy.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Ferimentos e Lesões / Fibrina / Adesivo Tecidual de Fibrina / Cicatriz / Sistema Nervoso Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Ferimentos e Lesões / Fibrina / Adesivo Tecidual de Fibrina / Cicatriz / Sistema Nervoso Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil