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Effectual components of Polygonum ciliinerve protects against Staphylococcus aureus infection with immunomodulatory functions in C57BL/6 mice
Cao, Lanxiu; lv, Juan; Zhao, Xian; Wang, Jiang; Ma, Li.
Afiliação
  • Cao, Lanxiu; Shanxi University. Department of Chinese Materia Medica. Shanxi. CN
  • lv, Juan; Shanxi University. Department of Chinese Materia Medica. Shanxi. CN
  • Zhao, Xian; Shanxi University. Department of Chinese Materia Medica. Shanxi. CN
  • Wang, Jiang; Shanxi University. Department of Chinese Materia Medica. Shanxi province. CN
  • Ma, Li; Shanxi University. Department of Chinese Materia Medica. Shanxi. CN
Acta cir. bras ; 33(11): 983-990, Nov. 2018. graf
Artigo em Inglês | LILACS | ID: biblio-973479
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the efficacy and mechanisms of root tuber of Polygonum ciliinerve (Nakai) ohwi (rPC) which has been used to treat bacterial infection in traditional Chinese medicine.

Methods:

With the mouse model of Staphylococcus aureus (S. aureus) pneumonia, the phenotype of rPC treated mice, including body weight, mortality, lung slices and bacterial burden were evaluated. Furthermore, inflammatory factors in bronchoalveolar lavage (BAL) were determined by ELISA and the distribution of T cells in lung was assessed by immunofluorescence assay.

Results:

rPC treatment could dose-dependently reduce weight loss and mortality in S. aureus-infected mice. Upon 10 mg/ml rPC treatment, S. aureus-infected mice showed about 8 grams increase in body weight (P<0.001) and 50% enhancement in mortality. The integrity of lung tissue and bacterial burden were also improved by rPC treatment. Moreover, rPC was found to modulate the immune response in infection.

Conclusion:

rPC has therapeutic potential for S. aureus infections and pneumonia with immunomodulatory functions.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Pneumonia Estafilocócica / Staphylococcus aureus / Medicamentos de Ervas Chinesas / Substâncias Protetoras / Polygonum / Imunomodulação / Antibacterianos Tipo de estudo: Estudo de Avaliação Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Shanxi University/CN