Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
Autops. Case Rep
; 8(4): e2018049, Oct.-Dec. 2018. ilus, graf
Artigo
em Inglês
| LILACS
| ID: biblio-986574
Biblioteca responsável:
BR26.7
ABSTRACT
5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the population demonstrate complete DPD deficiency, translating to extreme toxicity of 5-FU. Here we present a case of a patient who had a fatal outcome after treatment with 5-FU who was found to have an unknown DPD deficiency discovered at autopsy.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Deficiência da Di-Hidropirimidina Desidrogenase
/
Fluoruracila
/
Neoplasias de Cabeça e Pescoço
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
University of Chicago Medicine/US