Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair
Acta cir. bras
; 34(2): e201900203, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-989053
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair.Methods:
Fifteen rats were distributed to three groups MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldner's trichrome.Results:
The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect.Conclusion:
The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Materiais Biocompatíveis
/
Durapatita
/
Nanoestruturas
/
Alginatos
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
CBPF/BR
/
Faculdade Maria Milza/BR
/
UFBA/BR
/
Universidade Federal da Bahia/BR
/
Universidade Federal do Recôncavo da Bahia/BR