Estudios de conducción nerviosa periférica en pacientes con fallo múltiple de órganos / Periferical nerve conduction studies in patients wiht multiple organ failure

ABSTRACT

The polyneuropathy of critical diseases that often accompanies multiple organ failure (MOF) is one of thevarious causes that leads to the death of these patients. Aims. To evaluate the electrophysiological behaviour of peripheral nervesin patients with MOF. Subjects and methods. A prospective cross-sectional study was performed in 18 patients with MOF (the studygroup), 50 healthy subjects and 20 suffering from Guillain-Barré-Stroll-Landry syndrome (GBS) (the control groups). All of themwere submitted to sensory and motor peripheral nerve conduction studies. Results. The aetiology of this syndrome was varied 17patients required mechanical ventilation and 15 had difficulty in weaning. The main electrophysiological alterations in the studygroup consisted in a drop in amplitude with prolonged latency and duration, and slowed conduction velocities for the sensorypotentials of the median and posterior tibial nerves, while the lowered amplitude in motor nerve conduction was detected to a lesserdegree and intensity. On comparing them with those obtained in GBS, statistically significant differences were found. The greatestelectrophysiological alterations were detected in those who had difficulty in weaning -those who presented an unfavourable evolution.Conclusions. Subjects with MOF were found to have a predominantly sensory peripheral axono-myelinopathy which, onmonitoring it electrophysiologically, allows us to establish a prognosis regarding severity, evolution and gradually cutting thedependence on mechanical ventilation...(AU)