Comparison of treatment with tacrolimus 0.03% and superoxide dismutase and catalase in vitiligo

ABSTRACT

To compare the efficacy and safety of topical tacrolimus 0.03% with superoxide dismutase and catalase in vitiligo. This hospital based quasi-experimental study was carried out in out patients department of Dermatology Unit-II, Mayo Hospital Lahore in year 2006-2007. Patients were selected by non-probability purposive sampling method after obtaining an informed consent. Both sexes [above S years] were included with head and neck vitiligo. They were randomly divided into 2 groups; group 1 superoxide dismutase and catalase; group 2 tacrolimus by using random number table. There were 34[56.7%] females and 26[43.3%] males. Age of the patients ranged from 5 to 60 years with the mean age of 20.52 +/- 14.34 years. Overall 31[62%] patients showed repigmentation of varied grades. Repigmentation was shown by 14[46.6%] patients in superoxide dismutase and catalase group and 17[56.6%] patients in tacrolimus group. Topical superoxide dismutase and catalase and tacrolimus are effective treatment modalities in patients with vitiligo. There is no significant difference regarding efficacy and safety between both forms of treatment