Effect of pirprofen on prostaglandins, norepinephrine, serotonin and dopamine content of rat brain

ABSTRACT

Estimation of prostaglandin E [2] [PGE [2]] level and of the chemical transmitters, serotonin [5-HT], norepinephrine [NE] and dopamine IDA content was performed in different parts of the brain of rats given pirprofen [36 mg/kg] by I.M. injection. The results showed a decrease in PGE [2] content in the thalamus and hypothalamus, and in dopamine content of the striatum with a significant increase in the nerotonin level of the mid brain, however, there was insignificant inecrease in the norepinephrine [NE] level of pons and medulla. 5-HT/NE and 5-HT/DA ratios were found to be raised by pirprofen. These data may help to explain the mechanism of activities of pirprofen as a non-steroidal anti-inflammatory drug