Study of the influence of the antihistaminic mepyramine maleate on the epinephrine induced lipolysis in the rabbit

ABSTRACT

This study were conducted on 34 male rabbits which were divided into 4 groups Epinephrine group [6], mepyramine group [8], combined group [10], and a control group [10]. Fasting blood sugars were collected 20 minutes after epinephrine administration, 30 minutes after mepyramine administration to study the acute effects, other blood samples were collected after 7, 14, 21 days to study the effects of prolonged use by measuring the free fatty acids level, cholesterol, and triglycerides levels. It was found that mepyramine maleate induced a significant increase of plasma FFA with no change on cholesterol nor triglyceride levels. Prolonged use led to increasing both FFA, and cholesterol levels