effect of magnesium sulphate on the duration of epinephrine induced ventricular arrythmia in halothane anaesthetized dogs

ABSTRACT

The effect of magnesium sulfate infusion on the duration of epinephrine induced ventricular arrythmia was evaluated in halothane anesthetized dogs. MgSO4 infused at a rate of 8 mg/kg/min. for 20 minutes caused a significant reduction in epinephrine arrhythmic threshold dose. Twenty minutes infusion of MgSO4 [8 mg/kg/min.] were compared with propranolol [0.03 mg/kg/min.] and verapamil [0.5 mg/kg/min.] and saline infusion on the duration of arrhythmia after epinephrine [12 ug/kg] injection in halothane anesthetized dogs. MgSO4 and propranolol infusion caused a significant reduction in the duration of arrhythmia [85% and 75%, respectively]. Verapamil infusion caused a significant reduction from the control value, but only by 48%. There was no significant difference between MgSO4 and propranolol both caused a significant greater reduction in arrythmia than verapamil