Biochemical study on the effect of diazepam on serotonin, dopamine, norepinephrine and cholinesterase enzyme contents of rat brain

ABSTRACT

The levels of serotonin, dopamine, norepinephrine and cholinesterase in the brain of adult male albino rats injected intraperitoneally with Diazepam [10 mg/kg body weight, valium, Rochi] were studied after one and twelve hours post injectin. Diazepam exerted no significant change in brain cholinestrase activity, while a highly significant increase in brain serotonin [5 HT], dopamine and norepinephrine activities in male albino rats one hour after injection, was recorded, 36.9%, 30.9%, and 43.3% respectively, P < 0.001 such increased levels have been restored to normal levels twelve hours after administration