Value of complexed prostate specific antigen [CPSA] in detection of cancer prostate

ABSTRACT

This study was carried on 90 males aged from 40 to 81 years old selected from Al-Hussein Hospital [Al-Azhar University] in the period from August 2005 to August 2006. cases in this study were classified into 3 groups; Group I Included 20 persons who were apparently normal and without any prostatic disease and with normal digital rectal examination. Group II Included 50 patients with benign prostatic hyperplasia. Group III Included 20 patients histopathologically confirmed prostate cancer. The results revealed that there was statistically highly significant increase of complexed prostatic specific antigen[cPSA] in cancer prostate group in comparison to control group [p value 0.001]. A highly statistically significant decrease in Free/Total [F/T] ratio in cancer prostate group in comparison to control group. We found that cPSA is better in diagnosis of prostate cancer than total PSA but its performance was similar to that of F/T ratio except in sporadic cases in which performance of cPSA was better than F/T ratio. In addition, cPSA assay is a single test, measures a single analysis instead of two which is an economic advantage and decrease the chance of errors in diagnosis, it also uses a single set of kits with a single system of analysis. In addition, the complexed PSA is more stable than fPSA which is relatively unstable with long-term storage