Role of quercetin against 2-butoxyethanol induced micronucleus and chromosome aberrations in mice

ABSTRACT

EGBE is also known as 2-butoxyethanol [2BE]. EGBE is widely used as a solvent in various applications, such as in surface coatings, spray lacquer, quick-dry lacquers, enamels, varnishes, varnish removers, latex paint, metal cleaners, and in commercially available cleaning products. 2-Butoxyethanol causes cellular damage via formation of reactive oxygen species. Quercetin, a flavonol group of plant flavonoid, has generated interest because of its potential antioxidant, anti-proliferative, chemoprotective and anti-inflammatory properties. Quercetin exhibited significant antimutagenic and DNA-protective effects against oxidative damage due to the presence of hydroxyl groups in the molecule; it is considered an excellent free radical scavenging antioxidant owing to the high number of hydroxyl groups