study on Catalase Gene Promoter Polymorphism-21 A/T [rs7943316] in Healthy Pakistani population

ABSTRACT

Background and Objective: Catalase [CAT] is an important endogenous antioxidant enzyme that detoxifies H[2]O[2] into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT -21A/T [rs7943316] OMIM 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was designed to investigate the prevalence of mutant T allele frequency in healthy individuals