Aging and stem cell therapy: ampk as an applicable pharmacological target for rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy

ABSTRACT

In recent years, tissue regeneration has become a promising field for developing stem cellbased transplantation therapies for human patients. Adult stem cells are affected by the same aging mechanisms that involve somatic cells. One of the mechanisms involved in cellular aging is hyperactivation of mechanistic target of rapamycin complex 1 [mTORC1] and disruption of 50 adenosine monophosphate-activated protein kinase [AMPK]. Aging of stem cells results in their