Myosin light chain one [M.L.C.I], a diagnostic marker for acute myocardial infarction [A.M.I.]

ABSTRACT

Myosin light chain one [MLCI], total CPK and total LDH were estimated in 70 individuals; 40 patients with acute myocardial infarction [AMI]; [18 patients were successfully reperfused with streptokinase [STK] while the remaining 22 patients received conventional treatment] and 30 healthy persons as a normal control group. All patients were followed up by serial ECG. MLCI was measured by enzyme immunoassay reagents supplied by Yamasa Shoyu Co. Ltd. Tokyo, Japan, while total CPK and LDH were determined Colorimetrically by reagents supplied by Boehringer Mannheim GmbH Mannheim, Germany MLCI was of value in the diagnosis of AMI. MLCI persisted for 10 days, that is more than any enzyme and it is of value to make the diagnosis in patients who presented late i.e. after one week of the infarction in whom the ECG is equivocal and all enzymes returned to the normal level. Both MLCI and CPK were positive in 11% while LDH was positive in 2.7% of cases after 8hrs of the onset of chest pain [OCP]. This positivity went up to 88% for MLCI, 100% for CPK and 44% for LDH 24hrs after OCP in patients who had conventional treatment only. In patients who received STK, the positivity for these enzymes was 50%, 100% and 44% respectively 24hrs after OCP