Serum and synovial fluid chondroitin sulfate and keratan sulfate in osteoarthritis and rheumatoid arthritis

ABSTRACT

This study was performed to quantitate serum and synovial fluid chondroitin sulfate and keratan sulfate levels in patients with rheumatoid arthritis [RA] and osteoarthritis [OA] as well as levels in control sera and synovial fluid to evaluate their reflection of the disease process. This study was conducted on 22 RA patients, 22 OA patients and 10 control subjects. We measured serum and synovial level of chondroittn sulfate [CS] and Keratan sulfate [KS] and correlated their levels to the disease activity, our results slowed that serum KS levels were higher in patients with arthritic conditions than in controls [P < 0.05] No correlation was found between age, disease activity and CRP in RA and sera CS or KS. So measuring these markers may be valuable for evaluating the arthritic conditions