Serum immunoglobulin G and haematological parameters in goitrous thyroid disease treated by radioiodine and surgery

ABSTRACT

They were aimed at determining the serum immunoglobulin G [IgG] and hematological parameters in goitrous patients treated by radioiodine and thyroid surgery. This prospective clinicopathologic study was conducted in Postgraduate Medical Institute, Lahore. Blood samples of 20 patients with toxic diffuse goiter [TDG] and 30 with non-toxic nodular goiter were analyzed for serum IgG, hemoglobin [Hb], total and differential white cell counts [TLC and DLC] at 0, 10d and 6-8 weeks of radioiodine or surgical treatment. Twenty age-and.sex-mulched healthy individuals were included as reference population. Goitrous patients had significantly higher IgG that was detected after sub total thyroidectomy in cases of nodular goitre. Patients with TDG showed significantly increased IgG after radioiodine therapy [p<0.01]. Hb level in patients was lower as compared to control group [p<0.05], Hb showed a significant increase after 6-8 weeks of therapy [p<0.05]. Changes in TLC and DLC were not significant. Serum IgG in goitrous patients was significantly higher than healthy controls. Patients with TDG showed an increase in IgG after radioiodine therapy. Changes in Hb, TLC, DLC were mostly insignificant after treatment with radioiodine as well as surgery