effects of vitamins e and d supplementation on erythrocyte superoxide dismutase and catalase in atopic dermatitis

ABSTRACT

Atopic dermatitis is a public health problem worldwide. Increment of reactive oxygen species [ROS] production may be one of the contributing factors of tissue damage in atopic dermatitis. The present study was designed to determine the effect of vitamins E and/or D on erythrocyte superoxide dismutase and catalase activities in patients with atopic dermatitis. In a randomized, double blind, placebo controlled clinical trial 45 atopic dermatitis patients were divided into four groups. Each group received one of the following supplements for 60 days group A [n = 11] vitamins E and D placebos; group B [n= 12] 1600 international unit [IU] vitamin D3 plus vitamin E placebo; group C [n=11] 600 IU synthetic all -rac-a tocopherol plus vitamin D placebo; group D [nM] 1600 IU vitamin D3 plus 600 IU synthetic all -rac-a tocopherol. Erythrocyte superoxide dismutase [SOD] and catalase activities, serum 25 [OH] D, plasma a-tocopherol were determined. The data were analyzed by analysis of variance [ANOVA] and paired /test. After 60 days vitamin D and E supplementation, erythrocyte SOD activities increased in groups B, C and D [P= 0.002, P= 0.016 and P= 0.015, respectively]. Erythrocyte catalase activities increased in groups B and D [P= 0.026 and.P= 0.004, respectively]. The increment of erythrocyte catalase activity was not significant in group C. There was a positive significant correlation between SOD activity and serum 25 [OH] D [r= 0.378, P= 0.01]. It is concluded that vitamin D is as potent as vitamin E in increasing the activities of erythrocyte SOD and catalase in atopic dermatitis patients