Epidemiology of hepatitis A and E virus infection in Brazil
Gastroenterol. hepatol. (Ed. impr.)
; 28(3): 118-125, mar. 2005. mapas, tab
Artigo
em En
| IBECS
| ID: ibc-036354
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ES1.1
Localização: ES1.1 - BNCS
RESUMEN
This review has the objective to discuss the epidemiological aspects of the enterically transmitted hepatitis A and E in Brazil. The prevalence of hepatitis A varies greatly in differentBrazilian regions, from 56% in South and Southeast to 93% in North region (Manaus, Amazon). Such differences are also found in different socioeconomic levels among age groups. A significantly higher prevalence was seen in the low socioeconomic group between 1-30 years. This differenceis most striking in the first 10 years of age (23.5% vs 60.0%, high/middle vs low, respectively). Despite the improvementsin sanitary conditions, hepatitis A is still endemic and outbreaks may occur. As an increasing proportion of the population is becoming susceptible to hepatitis A virus infection and as adult individuals may present more severe forms of the disease, the authors conclude that the implementof hepatitis A vaccination should be considered. Some Brazilian data have shown that the genotype found in our country were IA and IB. Isolates from this study were closelyrelated genetically (or even identical) to isolates originatingin other South American countries and overseas, providingfirm evidence for epidemiological links between persons who travel to endemic areas. In spite of favorable environmental conditions, outbreaks of hepatitis E have never been reported in Brazil. Nevertheless,reports have demonstrated the evidence of anti-hepati-tis E virus antibodies in some Brazilian regions. The seroprevalenceof IgG anti-hepatitis E virus among normal populations shows positivities of 6.1% in gold-miners, 3.3% in general population, 2.0-7.5% in blood donors, 1.0% in pregnant women, and 4.5% in children, with no differences among regions. In populations at risk the prevalence of anti-hepatits E virus varies greatly. Among patients with acute non-A, non-B, non-C hepatitis 2.1% was detected in the Southeast to 29% in the Northeast, in 10.6% of acute non-A, non-B, non-C hepatitis relatives in the Amazon ba-sin, in 12% of acute sporadic non-A non-B hepatitis patientsin the Northeast, a co-infection with acute hepatitis A in 25 to 38% in the Northeast, in 14 to 18% among prostitutesand women considered at risk for human immunodeficiencyvirus in the Southeast, and in 12% of the intravenousdrug users in the Southeast
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Brasil
/
Hepatite E
/
Hepatite A
Tipo de estudo:
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Gastroenterol. hepatol. (Ed. impr.)
Ano de publicação:
2005
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of São Paulo School of Medicine/Brazil