Clinical and patient based evaluation of immunotherapy for grass pollen and mite allergy
Allergol. immunopatol
; 33(5): 264-269, sept. 2005. ilus, tab
Artigo
em En
| IBECS
| ID: ibc-042136
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ES1.1
Localização: ES1.1 - BNCS
ABSTRACT
Background:
Treatment of allergic disease can be done by pharmacological intervention by allergen avoidance in the following called standard care (SC), or by specific treatment with allergy vaccination; Specific Immunotherapy (SIT). The aim of this study were to evaluate the effects of subcutaneously administrated SIT compared to SC by objective (clinical/medical records) and subjective parameters (patient's opinion) in a before/after SIT study.Methods:
The study included retrospectively all grass- and mite allergic 16-60 year old patients (N = 253) who had started SIT for grass pollen or mite allergy during the period 1.1.1996-1.1.2002 at The Allergy Unit, Aarhus University Hospital, or at a specialist practice in Aarhus. Relevant data were collected before/after treatment from medical records and from a specific designed questionnaire. The following indicators for effect were applied Success of immunotherapy expressed as completion of up dosing phase, change in symptoms, a comparison of overall rhinoconjunctivitis symptoms, number of symptom free days per year, effect of pharmaceuticals, change in physical and psychological wellbeing and number of lost days from work/education and leisure activities.Results:
Compliance for completed up dosing for SIT was 94 % (95 % CI 90-97). The questionnaire revealed that after SIT there were a significant reduction in degree of symptoms, 84 % (95 % CI 79-89) of the respondents achieved a reduction in over all rhinoconjunctivitis score, there were an increase in symptom free days per year, a decrease in days off/incapacity from work/education and leisure activities, an improved effect of the pharmaceuticals used for allergic symptoms and an improvement in physical and psychological wellbeing. The study also showed that SIT was more effective treating rhinoconjunctivitis symptoms than lung symptoms.Conclusion:
The study revealed great advantages of SIT compared to SC and a high compliance for SIT during the up dosing periodRESUMEN
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Espanha
Base de dados:
IBECS
Assunto principal:
Pólen
/
Hipersensibilidade Respiratória
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Conjuntivite Alérgica
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Alérgenos
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Rinite Alérgica Perene
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Rinite Alérgica Sazonal
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Dessensibilização Imunológica
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Ácaros
Tipo de estudo:
Estudo de etiologia
Limite:
Adolescente
/
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2005
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universitet of Aarhus/Denmark
/
University Hospital of Aarhus/Denmark
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University of Southern Denmark/Denmark