Efect of periodontal disease and non surgical periodontal treatment onC-reactive protein. Evaluation of type 1 diabetic patients

ABSTRACT

Objectives: The purpose of this study was to analyze how anti-infectious periodontal treatment affects C reactiveprotein (CRP) values in patients with type 1 diabetes, and correlate baseline CRP levels with periodontal diseaseseverity.Study Design: A cohort of fifty three subjects with type 1 diabetes and moderate to severe periodontitis wererecruited. Periodontal parameters were measured, and blood samples were obtained to evaluate high-sensitivityC-reactive protein (hs-CRP). Group 1 was treated with scaling, root planning, and systemic administration ofdoxycycline. Group 2 received only scaling and root planning.Results: Hs-CRP was reduced after periodontal treatment in group 1 (-0.22 mg/l) and 2 (-0.21 mg/l ) but thisreduction was not statistically significant, even in the patients with the best response to periodontal treatment.However, significant correlation appeared between hs-CRP and mean probing pocket depth (PPD) (p=0, 01) andmean clinical attachment level (CAL) (p=0,03).Conclusions: Non-surgical periodontal treatment couldn’t reduce hs-CRP values, however, it was found an associationbetween advanced periodontitis and elevated blood hs-CRP levels in patients with type 1 diabetes. It canbe speculated that periodontal disease increases production of pro-inflammatory mediators in patients with type1 diabetes, but other producing sources of these pro-inflammatory substances may exist (AU)