Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)
Med. oral patol. oral cir. bucal (Internet)
; 18(6): 846-850, nov. 2013. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-117676
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objectives:
The objective of this study was to determine whether alterations in the expression of p53, caspase-3 Bcl-2, and ki-67 appear early in premalignant oral epithelium and show clonal behavior. StudyDesign:
Samples from 41 tumors with their adjacent non-tumor epithelia were immunohistochemically analyzed using monoclonal antibodies that recognize p53, caspase-3, Bcl-2, and Ki-67Results:
A statistically significant association was found between the expression in tumor and adjacent epithelium of p53, caspase-3, and Bcl-2 but not of k-67. A significant association was observed between the expression of ki-67 and p53 in both localizations. In non-tumor (premalignant) epithelium samples, there was a significant inverse relationship between the expressions of p53 and caspase-3 and a significant direct relationship between the expressions of p53 and Bcl-2.Conclusions:
Alterations in these proteins appear to operate in combination with premalignant epithelia to create hyperproliferative cell states that favor the acquisition of summative oncogenic errors that confer invasive capacity (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Proteína Supressora de Tumor p53
/
Antígeno Ki-67
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Genes bcl-2
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Tumor Odontogênico Escamoso
/
Caspase 3
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Campus de la Cartuja/Spain
/
Complutense University of Madrid/Spain
/
Hospital de Txagorritxu/Spain