Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine
J. physiol. biochem
; 68(2): 163-173, jun. 2012.
Artigo
em Inglês
| IBECS
| ID: ibc-122336
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and anti-inflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Ingestão de Energia
/
Imunidade Adaptativa
/
Imunidade Inata
/
Intestino Delgado
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Politécnico Nacional/México
/
UNAM/México