The effects of Weichangshu tablet on intracellular Ca2+ concentration in cultured rat gastrointestinal smooth muscle cells
J. physiol. biochem
; 67(2): 265-273, jun. 2011.
Artigo
em Inglês
| IBECS
| ID: ibc-122627
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
No disponible
ABSTRACT
The objective of this study was to explore the effects of Weichangshu tablets on free Ca2+concentration of the gastrointestinal smooth muscle cells of rats and the molecular mechanism of the Weichangshu tablets. Cultured SD rat gastrointestinal smooth muscle cells were divided into control group, Cisapride group, Weichangshu group, and control + ethylene glycol tetraacetic acid (EGTA) group, Cisapride + EGTA group, and Weichangshu + EGTA group. Laser scanning microscope and spectrophotometer detection were applied to detect the calcium concentration. The calcium concentrations in Weichangshu group and Cisapride group significantly increased vs. control, and those in Weichangshu group were higher than those in Cisapride group. Ca2+concentration in Weichangshu + EGTA group, Cisapride + EGTA group vs. control + EGTA group were not significantly different. Weichangshu could increase gastrointestinal smooth muscle free Ca2+ concentration, and this role may be achieved through the promotion of cells within the flow of calcium ions (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Medicamentos de Ervas Chinesas
/
Miócitos de Músculo Liso
/
Proteínas Sensoras de Cálcio Intracelular
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Binzhou Medical University/China