Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers
J. physiol. biochem
; 67(1): 15-26, mar. 2011.
Artigo
em Inglês
| IBECS
| ID: ibc-122630
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
No disponible
ABSTRACT
There are major variations in the susceptibility to weight gain among individuals under similar external influences (decreased physical activity and excessive calorie intake), depending on the genetic background. In the present study, we performed a microarray analysis and real-time PCR validations in order to find out differential gene expression in subcutaneous abdominal adipose tissue from two groups of subjects that despite living in similar environmental conditions such as a habitual high-fat dietary intake (energy as fat >40%) and similar moderate physical activity, some of them were successfully resistant (lean) to weight gain, while others were susceptible to fat deposition (obese). The classification of up- and downregulated genes into different categories, together with the analysis of the altered biochemical pathways, revealed a coordinated downregulation of catabolic pathways operating in the mitochondria fatty acid (..) (AU)
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Aumento de Peso
/
Ciclo do Ácido Cítrico
/
Complexo I de Transporte de Elétrons
/
Ácidos Graxos
/
Obesidade
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Parque Tecnológico de Zamudio/Spain
/
University of Navarra/Spain