Effect of vanadium on renal Na+, K+-ATPase activity in diabetic rats: a possible role of leptin
J. physiol. biochem
; 67(1): 61-69, mar. 2011.
Article
em En
| IBECS
| ID: ibc-122635
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
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ABSTRACT
Several researches attempt to protect diabetic patients from the development of nephropathy. Involvement of leptin and renal Na+,K+-ATPase enzyme in diabetic nephropathy (DN) development is a recent field for researches. Vanadium, as a trace element with insulin mimetic effect, may act synergistically with insulin to protect against the development of DN. Sixty male Sprague Dawley rats were divided into six groups control group (C), vanadium control group (CV), streptozotocin-induced diabetic group (D), insulin-treated diabetic group (DI), vanadium-treated diabetic group (DV), and combined insulin and vanadium-treated diabetic group. Six weeks later, systolic blood pressure (SBP) was measured and retro-orbital blood samples were collected to estimate glycosylated hemoglobin (HbA1c), serum sodium (Na+) and creatinine, blood urea nitrogen (BUN) and plasma leptin levels. Preparation of microsomal fraction of renal tissue homogenate for estimation of (..) (AU)
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Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Vanádio
/
ATPase Trocadora de Sódio-Potássio
/
Leptina
/
Diabetes Mellitus
/
Nefropatias Diabéticas
Limite:
Animals
Idioma:
En
Revista:
J. physiol. biochem
Ano de publicação:
2011
Tipo de documento:
Article