Ectopic expression of RBP4 impairs the insulin pathway and inguinal fat deposition in mice
J. physiol. biochem
; 70(2): 479-486, jun. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-122968
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
A large body of evidence has linked retinol-binding protein 4 (RBP4) to systemic insulin resistance, but little is known about its function in fat deposition. This study aimed to confirm the involvement of RBP4 in inguinal fat deposition and insulin by intraperitoneal injection of adenovirus-mediated RBP4 to mice. Intraperitoneal injection of adenoviral vectors was validated as an efficient gene manipulation tool for over-expressing recombinant proteins in vivo. Ectopic expression of RBP4 decelerated inguinal fat deposition by decreasing the size of adipocytes. Moreover, the introduction of exogenous RBP4 blunted the response of inguinal adipocytes to insulin signals. These findings suggest that RBP4 impaired in vivo adipogenesis, partly through the repression of the insulin pathway
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Proteínas de Ligação ao Retinol
/
Distribuição da Gordura Corporal
/
Adipogenia
/
Insulinas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Northwest A&F University/China