Telomerase and telomere dynamics in ageing and cancer: current status and future directions
Clin. transl. oncol. (Print)
; 9(3): 145-154, mar. 2007. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123282
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
This review will focus on the clinical utilities of telomerase for human cancer diagnosis and prognosis. Much attention has been focused on control of telomerase activity in early and late stage tumours. Telomerase stabilisation may be required for cells to escape replicative senescence and to proliferate indefinitely. Because of a very strong association between telomerase and malignancy, both clinicians and pathologists expect this molecule to be a useful diagnostic and prognostic marker and a new therapeutic target. These data have greatly inspired the development of various strategies to target telomere and telomerase for cancer therapy. Finally, evidence is now emerging that G-quadruplex ligands produce rapid senescence and selective cell death. A summary of recent experimental works with new small molecules as potential inhibitors of telomerase is presented (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Compostos Organoplatínicos
/
Envelhecimento
/
Biomarcadores Tumorais
/
Sequência de Aminoácidos
/
Telômero
/
Telomerase
/
Proteínas de Neoplasias
/
Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital de la Santa Cruz y San Pablo/Spain