Genomic instability: on the birth and death of cancer
Clin. transl. oncol. (Print)
; 9(4): 216-220, abr. 2007. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123295
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The presence of an abnormal chromosomal content is probably the most universally conserved hallmark of cancer cells. Predicted at the beginning of the 20th century as the origin of tumours, and extensively documented thereafter, genomic instability lies at the core of neoplastic development. Regardless of this classic model, the actual impact that deficient control of genomic integrity has on human health and particularly on cancer development only started to gain attention from the scientific community two decades ago. From a bird's eye view and with a cancer-oriented perspective, in this work we will try to cover some of the concepts obtained from recent research in genomic instability. The review will end up presenting suggestive evidence which proposes that genomic instability might turn out to be not just the driving force but also the Achilles' heel of cancer (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasia da Mama
/
Linfomas e Mieloma Múltiplo
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama
/
Ensaios Clínicos como Assunto
/
Instabilidade Genômica
/
Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Spanish National Cancer Center (CNIO)/Spain