Comprehensive lung injury pathology induced by mTOR inhibitors
Clin. transl. oncol. (Print)
; 11(8): 499-510, ago. 2009. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123667
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibroproliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Proteínas Quinases
/
Fibrose Pulmonar
/
Inibidores de Proteínas Quinases
/
Lesão Pulmonar
/
Pulmão
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
A Coruña University Hospital/Spain
/
Asturias Central Hospital/Spain
/
Oncology Research Lab, INIBIC/Spain