Angiogenesis and ovarian cáncer
Clin. transl. oncol. (Print)
; 11(9): 564-571, sept. 2009. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123678
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Ovarian carcinoma is the most important cause of gynaecological cancer-related mortality in Western societies. The age at diagnosis, extent of disease (as expressed by FIGO state), success of primary surgery and the histopathological features of the tumour are important prognostic markers. The majority of patients with ovarian cancer present with advanced disease (FIGO stage III/IV) and in this group of patients the median survival is only three years. New treatment approaches are therefore required to improve outcome in this disease. Angiogenesis, the development of a neovascular blood supply, is a critical step in the propagation of malignant tumour growth and metastasis and represents a promising target. This review will focus on angiogenesis, VEGF biology and the potential value of angiogenic factors with prognostic value in ovarian cancer (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Ovarianas
/
Ovário
/
Prognóstico
/
Carcinoma
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Neovascularização Patológica
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Infanta Sofía/Spain
/
Hospital Universitario La Paz/Spain