Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
Med. oral patol. oral cir. bucal (Internet)
; 19(3): e242-e247, mayo 2014. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-124718
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study DESIGN:
Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied.RESULTS:
Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p = 0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found.CONCLUSIONS:
NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
/
Álcool
Base de dados:
IBECS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Óxido Nítrico Sintase Tipo II
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Buenos Aires/Argentina
/
National University of Cordoba/s. p
/
National University of Cordoba/Argentina
/
School of Dentistry National University of Cordoba/s. p