Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion
J. physiol. biochem
; 70(3): 667-674, sept. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-127312
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Bile acids or its derivatives may influence non-alcoholic fatty liver disease development through multiple mechanisms. Intestinal L-cells secrete glucagon-like peptide-1 (GLP-1) and can be activated by bile acids (BA) influencing insulin resistance and hepatic steatosis development and progression. The aim of the present study was to assess the effects of cholic acid (CA) or ursodeoxycholic acid (UDCA) administration on portal and systemic levels of GLP-1 in genetically obese mice with established hepatic steatosis. Eight-week-old ob/ob mice were fed CA or UDCA during 4 weeks. Systemic and portal GLP-1 levels were measured as well as glucose tolerance test, serum and biliary parameters, hepatic triglyceride content, liver histology, and hepatic gene expression of relevant genes related to bile secretion. Eight-week-old ob/ob mice
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Espanha
Base de dados:
IBECS
Assunto principal:
Ácidos e Sais Biliares
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Fígado Gorduroso
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Obesidade
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/Chile