The clinical implicationof tumoral Gal-1 expression in laryngeal squamous cell carcinomas
Clin. transl. oncol. (Print)
; 15(8): 608-618, ago. 2013. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-127476
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
PURPOSE:
To explore the expression of tumoral Gal-1 in association with clinical parameters and outcome in a large population with laryngeal squamous cell carcinomas (LSCCs).METHODS:
A total of 187 patients with LSCC were retrospectively enrolled. Immunohistochemistry was performed to evaluate the tumoral expression of Gal-1, apoptosis-related proteins and the density of tumor infiltrating lymphocytes (TILs) in tumor tissues before any intervene. Survival curves were estimated by the Kaplan-Meier method, and differences in survival between groups were determined using the log-rank test. Prognostic effects were evaluated by Cox regression analysis.RESULTS:
A total of 102 carcinomas (54.5 %) were identified as high Gal-1 expression, and 85 carcinomas (45.5 %) as low expression. Tumoral Gal-1 expression was not significantly related with clinical stage and histology differentiation. No correlation of Gal-1 expression with apoptosis-related protein was identified. Instead, Gal-1 status was correlated positively with the ratio of FOXP3(+)/CD8(+) TILs (P = 0.024). In multivariate regression analysis, advanced clinical stage and the presence of metastases were identified as the independent predictors for poor survival in entire cohort. Especially, the statistical correlation between the Gal-1 expression and prognosis was particularly due to the late-stage tumors (P < 0.05).CONCLUSION:
Current results represent valuable advancements in Gal-1 research and provided further support for using Gal-1 as a diagnostic biomarker and immunotherapeutic target for LSCC (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Tirosina
/
Benzamidas
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
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Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Anhui Provincial Hospital N. 17/China
/
Sun Yat-sen University/China