TTD consensus document on the diagnosis and management of exocrine pancreatic cancer
Clin. transl. oncol. (Print)
; 16(10): 865-878, oct. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-127605
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Exocrine pancreatic cancer (PC) is a very aggressive and heterogeneous tumor with several cellular signaling pathways implicated in its pathogenesis and maintenance. Several risk factors increase the risk of developing PC. Therapeutic strategies used are dictated by the extent of disease. Supportive treatment is critical because of the high frequency of symptoms. For localized disease, surgery followed by adjuvant gemcitabine is the standard. Neoadjuvant and new adjuvant chemotherapy regimens are being evaluated. Locally advanced disease should respond best guided by a multidisciplinary team. Various treatment options are appropriate such as chemotherapy alone or chemoradiotherapy with integration of rescue surgery if the tumor becomes resectable. In metastatic disease, chemotherapy should be reserved for patients with ECOG 0-1 using Folfirinox or gemcitabine plus nab-paclitaxel as the most recommended options. Several therapeutic strategies targeting unregulated pathways are under evaluation with an unmet need for biomarkers to guide management (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Pancreáticas
/
Quimioterapia Adjuvante
/
Biomarcadores Farmacológicos
Tipo de estudo:
Estudo diagnóstico
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Estudo de etiologia
/
Guia de prática clínica
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Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Duran i Reynals/Spain
/
Hospital Regional Universitario Carlos Haya/Spain
/
Hospital Sanitas Millenium Iradier/Spain
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Hospital Universitario 12 de Octubre/Spain Madrid
/
Hospital Universitario Marqués de Valdecilla/Spain
/
Hospital Universitario Ramón y Cajal/Spain
/
Hospital Universitario de Elche/Spain
/
Hospital de Sabadell/Spain
/
Instituto de Salud Carlos III/Spain
/
Universidad Autónoma/Spain