Interferon-g +874A/T polymorphism is associated with asthma risk: a meta-analysis

ABSTRACT

Background: Results regarding the association between the interferon-g (IFN-g) +874A/T polymorphism and asthma risk are controversial and ambiguous. The aim of this study was to determine with greater precision the relationship between the IFN-g +874A/T polymorphism and asthma using a meta-analysis. Methods: Published literature was retrieved from 5 databases (PubMed, EMBASE, Wanfang, China National Knowledge Infrastructure [CNKI] and Weipu). ORs with 95% CIs were used to assess the strength of association. Results: Ten case-control studies involving 697 cases and 1049 controls were identified. In the overall analysis, a significant association between the +874A/T polymorphism and asthma susceptibility was found for AA vs AT + TT (OR, 1.89; 95% CI, 1.37-2.62; P=.0001). In the subgroup analysis by ethnicity, significant associations were found among whites (OR, 1.42; 95% CI, 1.04-1.93; P=.03) and Asians (OR, 2.52; 95% CI, 1.49-4.25; P=.0006). The sensitivity analysis and cumulative meta-analysis further strengthened the validity of this association. No publication bias was observed in this study. Conclusion: The results of this meta-analysis suggest that the IFN-g +874A/T polymorphism is a risk factor for asthma (AU)

RESUMEN

Antecedentes Los resultados de los estudios publicados sobre la asociacion entre el polimorfismo del interferon-g (IFN-g) 874 A/T y el riesgo de asma han sido polemicos y ambiguos. El objetivo de este estudio ha sido determinar, con mayor precision, la relacion entre el polimorfismo del IFN-g 874 A/T y el asma, usando un meta-analisis. Metodos: Busqueda de la literatura publicada en Pubmed, EMBASE, Base de Datos Wanfang, Infraestructura Nacional China de Conocimiento (CNKI) y en la base de datos Weipu. Se utilizaron los odds ratios (OR) con intervalos de confianza del 95% (IC) para evaluar la fuerza de la asociacion. Resultados: Se encontraron diez estudios de casos y controles, con 697 casos y 1049 controles. En el analisis general, se hallo una asociación significativa entre el polimorfismo 874 A/T y la susceptibilidad al asma, para AA vs AT + TT (OR = 1,89, IC del 95% 1,37 a 2,62, P = 0,0001). En el analisis de subgrupos, dependiendo de la etnia, se hallaron asociaciones significativas entre los caucasicos (OR = 1,42, IC del 95% 1,04 a 1,93, P = 0,03) y entre los asiaticos (OR = 2,52, IC del 95% 1,49 a 4,25, P = 0,0006). El analisis de sensibilidad y un meta-analisis acumulativo reforzaron aun mas la validez de esta asociacion. No se observaron sesgos de publicacion. Conclusion: Este meta-analisis sugiere que el polimorfismo del IFN-g 874 A/T es un factor de riesgo para el asma (AU)