A study comparing two consecutive historical periods in breast cancer with a focus on surgical treatment, loco-regional recurrence, distant metastases and mortality
Clin. transl. oncol. (Print)
; 17(4): 296-305, abr. 2015. tab, graf
Article
em En
| IBECS
| ID: ibc-134249
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background and aim:
Recent introduction of breast units, mass-screening programmes (SP) and sentinel node biopsy (SNB) has impacted on the clinical care of breast cancer patients (BC), resulting in a significant increase of breast-conserving surgery with the goal of achieving completely free margins and good cosmetic outcome, along with significantly less axillary morbidity. In order to ascertain the combined impact of SP and SNB on BC patients, we have reviewed the primary therapeutic approach of patients diagnosed with invasive breast carcinoma in our centre, both before and after implementation of the two new procedures.Methods:
1,942 patients operated for BC between 1997 and 2013 in two clinical centres. Two historical periods were considered before and after the advent of the Breast Unit in our institutions and the concurrent implementation of SP and SNB (September 2002).Results:
Rates of breast-conserving surgery and re-operations improved in the second period. Intraoperative margin re-excision increased in the second period. Breast-conserving surgery decreased in parallel to stage from 79 % for stage I to 31 % for stage III. The Cox analysis, including stage as adjusted for all significant variables, showed statistically significant differences in favour of the initial stages but only for specific mortality, not overall mortality.Conclusions:
Combined implementation of breast units, SP, and SNB have resulted in a significant improvement of BC treatment leading to increased rates of breast-conserving surgery and decreased disease recurrence and mortality (AU)RESUMEN
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Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama
/
Metástase Neoplásica
/
Recidiva Local de Neoplasia
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2015
Tipo de documento:
Article