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The influence of procarbazine and thiocyanate on embryonic bone maturation
Weingartner, J; Lieflander, S; Below, H; Fanghanel, J; Bienengraber, V.
Afiliação
  • Weingartner, J; University of Greifswald. Greifswald. Germany
  • Lieflander, S; University of Greifswald. Greifswald. Germany
  • Below, H; University of Greifswald. Greifswald. Germany
  • Fanghanel, J; University of Greifswald. Greifswald. Germany
  • Bienengraber, V; University of Rostock. Rostock. Germany
Eur. j. anat ; 8(1): 25-28, mayo 2004. tab, ilus
Article em En | IBECS | ID: ibc-137570
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
The substance procarbazine (Natulan®) is a teratogen known to induce cleft palates in rats on day 14 post-conception. The application of thiocyanate (SCN-) alone to rats on day 10 and 14 of pregnancy had no effects on fetal bone maturation. However, when procarbazine was used, the maturation and growth of fetal bones was delayed. Upon additional application of thiocyanate, the effects of procarbazine (Natulan) were increased. Thus, no antiteratogenic effect of thiocyanate occurs. We propose that charge and metabolites of teratogenic agents play a key role in developing the effects of thiocyanate (AU)
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Tiocianatos / Sistema Nervoso Central Limite: Animals Idioma: En Revista: Eur. j. anat Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Tiocianatos / Sistema Nervoso Central Limite: Animals Idioma: En Revista: Eur. j. anat Ano de publicação: 2004 Tipo de documento: Article